Synthesis of Biologically Relevant 1,2,3-and 1,3,4-Triazoles: From Classical Pathway to Green Chemistry - Archive ouverte HAL Access content directly
Journal Articles Molecules Year : 2021

Synthesis of Biologically Relevant 1,2,3-and 1,3,4-Triazoles: From Classical Pathway to Green Chemistry

(1, 2) , (1) , (3)
1
2
3

Abstract

Green Chemistry has become in the last two decades an increasing part of research interest. Nonconventional «green» sources for chemical reactions include micro-wave, mechanical mixing, visible light and ultrasound. 1,2,3-triazoles have important applications in pharmaceutical chemistry while their 1,2,4 counterparts are developed to a lesser extent. In the review presented here we will focus on synthesis of 1,2,3 and 1,2,4-triazole systems by means of classical and « green chemistry » conditions involving ultrasound chemistry and mechanochemistry. The focus will be on compounds/scaffolds that possess biological/pharmacophoric properties. Finally, we will also present the formal cycloreversion of 1,2,3-triazole compounds under mechanical forces and its potential use in biological systems.
Fichier principal
Vignette du fichier
Synthesis-of-Biologically-Relevant.pdf (8.75 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

hal-03360993 , version 1 (01-10-2021)

Licence

Attribution - CC BY 4.0

Identifiers

Cite

Lori Gonnet, Michel Baron, Michel Baltas. Synthesis of Biologically Relevant 1,2,3-and 1,3,4-Triazoles: From Classical Pathway to Green Chemistry: Review. Molecules, 2021, 26 (18), pp.5667. ⟨10.3390/molecules26185667⟩. ⟨hal-03360993⟩
45 View
58 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More