Generation of high drug loading amorphous solid dispersions by Spray Drying - IMT Mines Albi-Carmaux Access content directly
Conference Papers Year : 2019

Generation of high drug loading amorphous solid dispersions by Spray Drying

Abstract

Amorphous solid dispersions (ASDs) refers to drug - carrier systems, where the drug is dispersed in the carrier at a molecular level. In this work, ASDs were formulated by spray drying. The aim was to achieve high drug loads of an amorphous hydrophobic drug (Efavirenz - EFV) in the carrier Soluplus (R). Solid state characterizations (mDSC, XRPD, DVS, Raman, SEM, stability and solubility studies) were done. EFV amorphisation in ASDs (20 to 85% EFV loads) resulted in improved drug solubility compared to unprocessed EFV crystals and tendency of properties evolution over time for ASDs with EFV loads higher than 70 wt%.
Fichier principal
Vignette du fichier
7871-22509-2-PB.pdf (1.65 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

hal-02267499 , version 1 (19-08-2019)

Licence

Attribution - NonCommercial - NoDerivatives

Identifiers

Cite

Bhianca Lins de Azevedo Costa, Martial Sauceau, Romain Sescousse, Maria-Inês Ré. Generation of high drug loading amorphous solid dispersions by Spray Drying. IDS 2018 - 21st International Drying Symposium, Sep 2018, Valence, Spain. pp.1123-1130, ⟨10.4995/ids2018.2018.7871⟩. ⟨hal-02267499⟩
128 View
224 Download

Altmetric

Share

Gmail Facebook X LinkedIn More