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Article Dans Une Revue Journal of Supercritical Fluids Année : 2006

Solubility of carbon dioxide in three lipid-based biocarriers

Résumé

Equilibrium data of the solubility of carbon dioxide in Precirol(R) ATO5, Compritol(R) 888 ATO and Gelucire(R) 43-01, three solid lipid carriers suitable for controlled/sustained delivery, were measured by a static analytical method for three different temperatures each, in a pressure range from 10 to 20 MPa. The influence of the presence of carbon dioxide in the melting point of the lipid matrices was also studied by a visual method for pressures up to 30 MPa. All the compounds studied presented a similar behaviour in the presence of carbon dioxide, showing a decrease in the melting points between 5 and 13 degrees C, whereas the solubility of carbon dioxide varies from 0.3 to 0.5 g/g of lipid compound. These results are of utmost importance to design supercritical fluid processes for particle formation at lower operating costs.
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Dates et versions

hal-01618301 , version 1 (13-12-2017)

Identifiants

Citer

A. R. Sampaio De Sousa, Marilyn Calderone, Élisabeth Rodier, Jacques Fages, Catarina M. M. Duarte. Solubility of carbon dioxide in three lipid-based biocarriers. Journal of Supercritical Fluids, 2006, 39 (1), pp.13-19. ⟨10.1016/j.supflu.2006.01.014⟩. ⟨hal-01618301⟩
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