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Communication Dans Un Congrès Année : 1997

Supercritical processing enhances viral safety and functionality of bone allografts

Résumé

A new bone tissue process using supercritical carbon dioxide extraction has been checked for viral inactivation and allografts, thus processed, for bone integration. Four viruses, human immunodeficiency virus type I (HIV-I), Sindbis virus, Polio Sabin type-I virus, and Pseudorabies virus (PRV) and four processing stages, supercritical CO2, hydrogen peroxide, sodium hydroxide and ethanol treatments were tested. The cumulated reduction factors (log10) were the following: >18.2 for Sindbis virus, >24.4 for polio virus, >17.6 for PRV and >14.2 for HIV-I. Such processed allografts were implanted into sheep leading to a much faster osseointegration in comparison with non-treated allografts. Better graft incorporation in addition to viral safety suggest that this process could become a new way for processing bank bones, alternatively or additionally, to the procedures presently used.
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hal-01808932 , version 1 (13-09-2018)

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  • HAL Id : hal-01808932 , version 1

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Jacques Fages, Didier Mathon, Béatrice Poirier, André Autefage, Daniel Larzul, et al.. Supercritical processing enhances viral safety and functionality of bone allografts. 4TH INTERNATIONAL SYMPOSIUM ON SUPERCRITICAL FLUIDS, International Society for the Advancement of Supercritical Fluids (ISASF) - Tohoku University, May 1997, Sendai, Japan. ⟨hal-01808932⟩
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