Dispersion of an Active Pharmaceutical Ingredient in Eudragit E100 by Melt Extrusion Coupled with Supercritical Carbon Dioxide - Archive ouverte HAL Access content directly
Conference Papers Year : 2013

Dispersion of an Active Pharmaceutical Ingredient in Eudragit E100 by Melt Extrusion Coupled with Supercritical Carbon Dioxide

(1) , (2) , (2) , (1) , (1) , (2)
1
2

Abstract

The plasticising effect of supercritical CO 2 during the solvent-free melt extrusion of the cationic copolymer Eudragit E and the heat-sensitive and slowly dissolving active pharmaceutical ingredient, spironolactone was shown to reasonably improve the purity of the prepared solid dispersions by enabling production at lower temperature ranges. By increasing the mass flow of the melt, further enhancement was achieved in purity, but the shorter residence time counteracted the amorphisation (i.e. molecular dispersion) of crystalline drug particles, according to data acquired by confocal Raman mapping. At the same time, supercritical CO 2 aided amorphisation of the lipophilic drug, thus also facilitating the production of fully amorphous glassy solution samples at the lowered temperature. The obtained high amorphicity ensured immediate drug dissolution in acidic medium. Scanning electron microscopy revealed that optimal extrusion parameters enabled the production of foams of low porosity, homogeneous structure and thin walls.
Fichier principal
Vignette du fichier
Vigh-Belgrade-2013.pdf (3.34 Mo) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

hal-01730313 , version 1 (13-03-2018)

Identifiers

  • HAL Id : hal-01730313 , version 1

Cite

Tamás Vigh, Martial Sauceau, Élisabeth Rodier, Zsombor K Nagy, György Marosi, et al.. Dispersion of an Active Pharmaceutical Ingredient in Eudragit E100 by Melt Extrusion Coupled with Supercritical Carbon Dioxide. 6th International symposium on High Pressure Processes Technology - EFCE event N°708, EFCE Working Party on High-Pressure Technology and Association of Chemical Engineers of Serbia, Sep 2013, Belgrade, Serbia. p.33-39. ⟨hal-01730313⟩
88 View
194 Download

Share

Gmail Facebook Twitter LinkedIn More